For the past twenty years in the fields of cardiology, heart, and vascular surgery, Cleveland Clinic has been ranked and regarded as the best and highest-performing hospital in the world.

As of 2019, it has over 67,500 employees, a figure that includes over 17,000 registered nurses and advanced practice providers and over 4,520 physicians and scientists in 140 specialties.

In addition, Cleveland Clinic has 1,974 residents and fellows in 104 training programs approved by the Accreditation Council for Graduate Medical Education (ACGME).

[15] The organization grew out of the surgical practice of Frank J. Weed (died 1891) at 16 Church Street on the near-west side of Cleveland.

[18][19] In 1892 they were joined by Crile's cousin, William E. Lower,[20] and in 1897 the practice moved to the Osborn Building on Prospect Avenue, downtown Cleveland.

[25][26] To meet rising patient volume, a 184-bed hospital was built in 1924, located at East 90th Street and Carnegie Avenue.

[31] Philanthropist Samuel Mather formed a committee of 36 community leaders to help Cleveland Clinic reestablish itself in temporary quarters across the street.

[38] Willian S. Kiser, chairman of the board 1977–1989,[39] led the development of a strategic plan to accommodate growing patient volumes in the late 1970s.

[41] The Cleveland Clinic Lerner Research Institute (LRI) conducts biomedical research in a 480,000-square-foot building that opened in 1999,[42] following a $16 million donation from Al and Norma Lerner in 1997, the largest single charitable donation made to the Cleveland Clinic up until that point.

[46] Physician researcher Eric Topol played an important role in securing the donation from the Lerner family.

[47] Topol served as Provost and Chief Academic Officer at CCLCM until 2006, when his position was eliminated amid controversy regarding his criticism of Vioxx and disagreements with other Cleveland Clinic leaders, including then-CEO Toby Cosgrove.

[58] In addition, for the 14th year in a row, Cleveland Clinic was ranked as the #1 hospital in the United States for cardiology and heart surgery as a specialty.

[60] In 2022, The American Hospital Association (AHA) partnered with the Society for Healthcare Strategy and Market Development to engage the branding agency, Monigle, to conduct consumer research with 28,000 Americans to rank hospital brands °… on their performance in delivering a humanized experience".

[62] Between 2010 and 2013, CMS undertook an extensive series of investigations into the Cleveland Clinic Foundation, with at least a dozen inspections and follow-up visits triggered by patient complaints.

Due to numerous serious ongoing safety violations, the Cleveland Clinic Foundation was on payment termination track for 19 months, placing at stake $1B in annual Medicare/Medicaid reimbursement.

[66] During the early phase of the COVID-19 pandemic, administration at the Cleveland Clinic initially instructed employees that they were not allowed to wear face masks outside of patient care areas.

[67] The Cleveland Clinic stated they made this decision as they felt the current body of evidence at the time did not support their use.

[71] Cleveland Clinic operates 19[3][4] family health and ambulatory surgery centers in surrounding communities, a 1,000 bed multispecialty hospital and family health center in Weston, Florida, and two Cleveland Clinic Canada locations in Toronto, Canada.

[79] In February 2021, Mercy Medical Center in Canton, Ohio became a full member of the Cleveland Clinic health system, while retaining its Catholic affiliation through sponsorship with the Sisters of Charity of St.

[83] Cleveland Clinic Akron General’s Paramedic Education Program was initiated in 1976 as a commitment to the community in providing pre-hospital care to citizen within Summit County and adjoining areas.

[84] The hospital is also an American College of Surgeons verified Level 1 Trauma Center, the one of three in the region and one of 11 in Ohio, the other two in Cleveland.

The hospital provides comprehensive pediatric specialties and subspecialties to infants, children, teens, and young adults aged 0–21 throughout Cleveland and the wider northern Ohio region.

[95] The organization began work renovating an historic building at 33 Grosvenor Place in central London, England, in 2018.

Demolition of the interior of the six-story, 198,000-square-foot building allowed for the conversion to a hospital,[96][7] with Cleveland Clinic London opening in March 2022.