Brito was signed by the Philadelphia Phillies on July 3, 1998, as a non-drafted amateur free agent.

Brito had begun 2006 spring training with the Phillies, but when he returned from the WBC, the team optioned him to the Triple-A International League Scranton/Wilkes-Barre Red Barons.

Despite his having notched one last MLB victory, achieved during a late-season cup of coffee with Philadelphia, Brito was granted free agency, on October 29, 2007.

He began the 2008 season with the Double-A Eastern League Harrisburg Senators and quickly earned a promotion to Triple-A, before being released, on April 16, 2008.

On April 22, 2008, he signed a minor league contract with the New York Mets, subsequently playing at their Double- and Triple-A levels.