His demise was occasioned by his involvement in a plot against the Muslim king of Kartli, Rostom-Khan, who had him arrested and put to death in prison.

In 1633, Teimuraz was ousted from Kartli by the Muslim Georgian prince Rostom, who declared himself king and was confirmed by the shah of Iran as a wali.

[1][2][3] After Rostom's accession to the throne of Kartli and his strategically calculated marriage to Mariam Dadiani, a devout Christian princess from Mingrelia, Eudemus found in her an influential protector of the Christian church, but he remained in opposition to Rostom, accusing him of transplanting Iranian and Muslim customs into Georgia.

In 1642, Eudemus joined the noblemen—Zaal, Duke of Aragvi, Nodar Tsitsishvili, and Giorgi Gochashvili—in a plot to assassinate Rostom and restore Teimuraz in Kartli.

His body was cast off a tower, retrieved by a group of Christians and buried in the northwest corner of Anchiskhati church in Tbilisi.