In 1911, he returned to the state of Morelos, where he joined the Maderista movement, led by Pablo Torres Burgos and his brother Emiliano to fight the dictator Porfirio Díaz.

In August, he was commissioned by his brother Emiliano Zapata to meet and finalize an agreement with Francisco I. Madero, in Tehuacán, Puebla.

In 1912, he operated in the south and west of Puebla, where he carried out, together with his brother, efforts to take the state capital during the month of March.

In April 1914, he attacked and occupied haciendas and towns in southern Puebla, finally settling in Cuautla in August, where he appointed commissions of farmers with good local standing to carry out the agrarian work of land distribution.

He was assassinated on June 18, 1917, in Cuautla, by General Sidronio Camacho, a subordinate alleging that Eufemio had beaten his father.