[1][2] Following the Russian Revolution of 1917, Botkin went into exile with the Romanov family, accompanying them to Tobolsk and Yekaterinburg in Siberia.

On 3 February 2016, the Bishop's Council of the Russian Orthodox Church canonised Botkin as Righteous Passion-Bearer Yevgeny the Physician.

[5] He served with distinction aboard the St. Georgievsky Red Cross hospital train and wrote notes on the Russo-Japanese War.

His marriage broke up under the strain caused by Botkin's dedication to the Romanovs and his long hours at court.

The doctor also often spoke with Tsarina Alexandra in her native German and acted as a translator for her when she received a Russian delegation.

It was written in his quarters on the night of 16 July 1918: I am making a last attempt at writing a real letter – at least from here – although that qualification, I believe, is utterly superfluous.

Again – this is not a hallucination because the word was pronounced, the voice was similar, and I did not doubt for an instant that my daughter, who was supposed to be in Tobolsk, was talking to me ...

This vindicates my last decision ... when I unhesitatingly orphaned my own children in order to carry out my physician's duty to the end, as Abraham did not hesitate at God's demand to sacrifice his only son.

[9]The letter was interrupted when Yakov Yurovsky, the head of the command at the Ipatiev House knocked on Botkin's door.

[9] In the early 1990s, after the unmarked gravesite had been discovered and Botkin's remains were examined, he was found to have had bullet wounds on his legs, pelvis, vertebrae, and forehead.