Eugene Lindsay Opie (July 5, 1873 – March 12, 1971) was an American physician and pathologist who conducted research on the causes, transmission, and diagnosis of tuberculosis and on immunization against the disease.

[4] In 1904, Opie moved to New York City to work at the Rockefeller Institute, with a focus on the enzymatic constituents of leukocytes and their role in inflammatory conditions.

He served in France as a colonel (O6) in the Medical Corps, with special work on infectious diseases and their prevention among allied soldiers.

Opie narrowed his general interest in infectious disease to focus on tuberculosis, an international scourge in the early part of the 20th century.

Through Opie's work over the next decade, much was learned about the modes of tuberculous infection in children and adults, as well as aspects of immunity, hypersensitivity, and cellular defenses regarding that disease.

There, as chair of the Pathology department, he recruited several young pathologists—including Robert A. Moore, D. Murray Angevine, Jules Freund, and others – who would all go on to distinguish themselves as renowned investigators in their own rights.

[10][11] In addition to infections, Opie did work on hepatic carcinogenesis, alterations in nucleic acid content in various disease states,[12] and tissue fluid flux.