Eugene Leroy Mercer (October 30, 1888 – July 3, 1957) was a respected surgeon but was best known for his college football career while attending the University of Pennsylvania.

During his time at Penn, Mercer helped the Quakers to a 23–10 football record and received All-American honors in 1910, 1911 and 1912.

He later worked at Swarthmore College as the school's athletic director and as a physical education professor.

Mercer returned to Penn in 1930 to serve as the Director and Dean of the school's Physical Education Department.

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