[4] Suarez began the 2014 season with Erie, and was promoted to the Toledo Mud Hens of the Class AAA International League in May.

On June 7, Suarez made his first major league start in a game against the Boston Red Sox, and recorded his first hit, a solo home run.

[12] With the Todd Frazier trade to the Chicago White Sox, the Reds announced Suárez would be moved to third base full-time, with Zack Cozart returning to shortstop after his stint on the disabled list.

[21][22] On January 28, 2020, it was revealed that Suárez underwent right shoulder surgery to remove torn, loose cartilage, an injury that occurred during a swimming pool mishap at his residence in Pinecrest, Florida.

[24][25] During the shortened 2020 season, Suárez hit .202/.312/.470 with 15 home runs and 38 RBIs in 57 games, and was fourth among NL third basemen in errors, with five.

"[26] On March 14, 2022, the Reds traded Suárez and Jesse Winker to the Seattle Mariners in exchange for Justin Dunn, Jake Fraley, Brandon Williamson, and a player to be named later, later announced to be Connor Phillips.

On September 7, he recorded his 1000th career hit with a 2-run home run off Chicago White Sox pitcher Michael Kopech.

On September 11, Suárez homered twice in an 8–7 win over the Atlanta Braves, helping to atone for a blown 4-run lead in the top of the 9th by taking Kenley Jansen deep for a walk-off solo shot.

[31][32] On November 22, 2023, the Mariners traded Suárez to the Arizona Diamondbacks in exchange for reliever Carlos Vargas and catcher Seby Zavala.