He started the year with the AA Connecticut Defenders, but he played so well he earned a promotion to the AAA Fresno Grizzlies.

His first appearance of the season came in the Giants' 10–4 victory to complete a three-game sweep of the Houston Astros at Minute Maid Park on April 7.

He entered the contest replacing Mark DeRosa in left field as part of a double switch in the seventh inning.

It was the second year in a row that Majestic Athletic, MLB's official uniform supplier, committed a jersey misspelling.

On July 26, while sitting in the dugout during a Giants' 10–4 win over the Arizona Diamondbacks, Vélez was struck in the head by a foul ball, coincidentally off the bat of Burrell, and hospitalized briefly afterward.

On December 13, 2010 he signed a minor league contract with an invite to spring training with the Los Angeles Dodgers.

On August 22, Vélez tied J. D. Drew for the worst offensive start for the Dodgers since 1919 by failing to get a hit in his first 25 at-bats.

He also extended his overall hitless streak to 46 at-bats, breaking the record previously shared by Bill Bergen, Dave Campbell and Craig Counsell.

[10] Vélez returned to the Blue Jays organization in December 2012 by signing a minor league contract, with a spring training invitation.

[12] Vélez signed a minor league contract with the Milwaukee Brewers on July 26, 2013, and was assigned to the Triple-A Nashville Sounds.

In December 2022, the First Collegiate Court of Santo Domingo Province sentenced Vélez and his brother to prison for 10 years for arms trafficking.

Then, the Public Prosecutor’s Office searched the home of Vélez and his brother, where they found a Walther brand pistol, model P22, 22 mm caliber, with its charger and six capsules, all of them illegal.

Vélez and his brother were accused of belonging to a criminal network that was dedicated to illegally buying, trading and distributing firearms in the territory of the Dominican Republic.