Born in West Germany, she attended Ohio State University and Yale Law School.

[3] She graduated from Ohio State University in 1993 with a Bachelor of Arts degree, summa cum laude.

[4] Lee began her legal career as a law clerk for Judge Susan J. Dlott on the United States District Court for the Southern District of Ohio from 1996 to 1997, and Judge Eric L. Clay on the United States Court of Appeals for the Sixth Circuit from 1997 to 1998.

[4] On January 26, 2022, it was speculated by some media outlets that Lee would be considered by Joe Biden as a nominee to replace Stephen Breyer on the U.S. Supreme Court.

[7] During her confirmation hearing, she distanced herself from the contents of a letter she wrote as an Ohio State undergrad in 1991, which talks about Thomas being a "black conservative.

[16] In 2021, New York City school administrators and teachers filed suit to halt the vaccine mandate that was implemented due to the COVID-19 pandemic.