It is native to the eastern and central United States, found from Maine south to North Carolina and Alabama, and west as far as Arkansas, Kansas, and Minnesota.

The leaf bases are rounded and the leaves are sessile (lacking stalks), but they do not clasp around the stem.

Eupatorium sessilifolium blooms in August and September (July in the southern part of its range), and the small inflorescences are branched and composed of widely spaced, tiny white flower heads in corymbiform (flat topped) arrays.

[7] Upland boneset is a threatened species in Michigan, and legally protected in that state.

[8] It is also a threatened species in Minnesota, where only a few populations exist in the extreme south eastern part of the state.