Unlike most of the band's previous releases, "Euphoria" takes a much more aggressive and post-hardcore inspired direction with its instrumentals.

[3] Prior to the song's release, DeLonge had also made numerous social media posts saying that the upcoming album would take inspiration from his and guitarist David Kennedy's previous band, Box Car Racer, which has also been cited as having a post-hardcore sound.

[6] "Euphoria" was released alongside the band announcing two headlining shows in New York City and Los Angeles, and an appearance at Lollapalooza 2021.

[8][9] Shortly after the release of Lifeforms, "Euphoria" was added as downloadable content for the video game, Rock Band.

The video depicts a romantic relationship between a young woman and a man who works at Area 51.