The medical journal publishes both clinical and scientific papers on all aspects of cardiovascular medicine.

It includes articles related to research findings, technical evaluations, and reviews.

In addition, the journal features reviews, clinical perspectives, podcasts, and editorial articles about recent developments in cardiology, and encourages correspondence from its readers.

Another important aspect of the journal are the ESC Clinical Practice Guidelines, which cover all areas of cardiology.

Thomas F. Lüscher (Royal Brompton and Harefield Hospital Trust and Universität Zürich) was succeeded by Filippo Crea as the editor-in-chief.