In January 2010, Tim Howell became CEO of Euroclear, replacing Pierre Francotte whose tenure lasted 10 years.

[7] In May 2013, Euroclear and the US' Depository Trust and Clearing Corporation offered access to each other’s vast inventory of collaterals.

While the initial offering provides a two-way automatic transfer and retention of collaterals, it is intended to evolve as a single pool of depositories.

[8] In April 2014, Euroclear linked its system to the Central Latinoamericana de Valores to open Panama to international investors, thus creating a single pool of liquidity.

[9] In February 2015, Mexico opened up its corporate bonds to Euroclear's trading platform, hoping it will facilitate and increase raising funds for its development programs.

[17] In an article in Foreign Affairs and in a subsequent interview, economist Benn Steil, a senior fellow and director of international economics at Council on Foreign Relations (CFR), and CFR analyst Benjamin Della Rocca argued that Russia may have - in transactions executed through the Central Bank of China and then likely through Chinese state-owned banks as intermediaries - deposited $80 billion in U.S. Treasury bonds at Euroclear in the buildup to the 2022 Russian invasion of Ukraine.

[21][22] Euroclear settles domestic and international securities transactions, covering bonds, equities, derivatives, and investment funds.

On 25 March 2015, New York federal judge Thomas Griesa ordered Euroclear to stop processing payments of Argentina's debt bonds.

[26] The intent of this injunction was to force Argentina to fully pay their creditors in order to gain back access to its bond-selling program.