Consequentially, the MMCC/EMC was formed, celebrating its Initial Operation Capability (IOC) on 3 and 4 September with an opening ceremony at the Ehrenbreitstein Fortress and Rhine-Barracks in Koblenz, Germany.

[citation needed] Signing the Declaration of Initial Operational Capability MMCC/EMC during the COMEDs Plenary in Brussels on 27 November 2019, Slovakia became the 15th member nation.

On May 11, the 30th Medical Brigade Commander Colonel Jason Wieman and MMCC/EMC Director Surgeon General Dr. Stefan Kowitz signed the protocol for the assignment of a United States Army Europe and Africa (USAREUR-AF) Liaison Officer to MMCC/EMC in Koblenz.

[4] In August 2022, the MMCC/EMC continued to consolidate its network of international contact points through an agreement with the Confédération Interalliée des Officiers Médicaux de Réserve (CIOMR).

Another major exercise of the MMCC–E, “Casualty Move 2024” (CAMO24), was conducted in September 2024 and focused on "a major joint operation scenario with activation of the collective defence and mutual assistance clauses to train the national echelons of health crises management on bulk patient flow with the prospect of a enhanced civil-military cooperation.” In autumn 2023, the representatives of the MMCC/EMC participating nations agreed to change the name to “Multinational Medical Coordination Centre – Europe”, in short “MMCC-E”.