Among the places included in its itinerary are: Since October 2007 construction works have started on a new railroad between Schaerbeek and Mechelen on the central reservation of the E 19 (Belgian A1) with the purpose of improving the train connection between Antwerp, Brussels Airport and Brussels.

In the Netherlands, the E19 starts in Amsterdam on the A4 to pass Through to the Hague, where it switches to the A13 to run Delft and to Rotterdam.

At Zwijndrecht it passes through the Drechttunnel as it goes on to Dordrecht, over the Moerdijkbruggen, following to the city of Breda and crossing the border at Hazeldonk/Meer into Belgium.

At the junction of Graincourt-lès-Havrincourt near Cambrai, the E 19 joins the Autoroute des Anglais E 17.

It arrives in the agglomeration of Paris and meets the Francilienne, also known as A104, near the airport of Paris-Charles de Gaulle and then the A170 at the junction of Gonesse.