Unlike most routes, the E751 centers on the Kanfanar interchange and has three arms, each extending to Rijeka, Pula and Koper.

[5] Following the northern terminus of the A9 motorway in the Umag interchange, the E751 switches to the 0.6-kilometre (0.37 mi) D510 connector and the northernmost section of the D21 state road running to the Kaštel/Dragonja border crossing to Slovenia.

[9] Thus, unlike most routes, the E751 centers on a central interchange, Kanfanar, and has three arms, each extending to Rijeka, Pula and Koper.

[10] The E751 route is of great importance for economy and tourist industry of Istria and Slovenian Littoral, as it links many resorts to motorway systems in Slovenia and Croatia, providing a significant access route for thousands of motoring tourists.

These resorts include Brijuni National Park, Fažana, Rovinj, Poreč, Novigrad, Umag, Piran and Portorož on either side of the Croatian–Slovenian border.

[13] Although A8 also employs a ticket system, usage of the road is free except for vehicles traversing the Učka Tunnel and the Kanfanar–Rogovići section.

[16] The United Nations Economic Commission for Europe was formed in 1947, and their first major act to improve transportation was the joint UN declaration numbered 1264.

Signed in Geneva on 16 September 1950, it was named the Declaration on the Construction of Main International Traffic Arteries,[17] which defined the first E-road network.

This declaration was amended several times before 15 November 1975, when it was replaced by the European Agreement on Main International Traffic Arteries (AGR), which established a route-numbering system and improved standards for roads on the list.

[21] The remaining unbuilt section of the motorway is a short connection to the Slovenian border and planned H5 expressway.

[26] Limska Draga and Mirna viaducts were still two-lane expressways, and construction on the H5 section concurrent with E751 had not yet begun.