Eustace de Vesci (1169–1216) was an English lord of Alnwick Castle, and a Magna Carta surety.

Eustace was a leader during the Barons' War in 1215 and was killed while undertaking a siege of Barnard Castle in 1216.

A tale of John's attempted seduction of his wife, and the trick played on him, first appears in Walter of Hemingburgh and bears a close resemblance to a classical model.

His lands were seized, but after John's submission to the pope he was forced to invite Vescy back (27 May 1213), though orders were sent on the same day to Philip of Oldcoates to cripple him by destroying his castle of Alnwick.

[6] He was killed at a siege of Barnard Castle; while he accompanied Alexander II of Scotland on his way to do homage to Louis of France, on the way they laid siege to Barnard Castle, belonging to Hugh de Balliol, and, approaching too near, Vescy was shot through the head by an arrow.