It is named after Euston Hall, the family seat of the Dukes of Grafton, who had become major property owners in the area during the mid-19th century.

Traffic increased when major railway stations, including Euston, opened in the mid-19th century and led to the road's renaming in 1857.

[1] Bus routes 30 and 205 run along the entire extent of Euston Road from Great Portland Street to King's Cross.

[3] A clause in the 1756 Act stipulated that no buildings should be constructed within 50 feet (15 m) of the road, with the result that most of the houses along it lay behind substantial gardens.

It was planned by Robert Stephenson on the site of gardens called Euston Grove, and was the first mainline station to open in London.

It was built in the early 1860s over a former reservoir to provide affordable middle-class terraced housing but its proximity to a main road and the Euston Station complex meant it ultimately catered for the working classes.

The estate continued to expand throughout the early 20th century in a piecemeal fashion, and attracted Greek, Cypriot and Asian immigrants following World War II.

[14] In the 1970s, the estate came under threat from property developers who wanted to demolish it and build offices, which led to demonstrations and protests, including supporters from University College.

[15] An underpass to avoid the junction with the Tottenham Court Road was proposed by the London County Council (LCC) in 1959,[16] with construction beginning in 1964.

[20][21] In the early-21st century, the Greater London Authority commissioned a plan to improve the road from the architectural firm, Terry Farrell and Partners.

The scheme was approved by the Mayor of London, Ken Livingstone as "the start of changing the Marylebone to Euston road from a highway into a series of linked public spaces.

[23] Livingstone's successor, Boris Johnson, favours keeping the Euston Road underpass and declared it to be a good place to test his nerves when cycling around London.

[24] In 2015, Transport for London announced its intention to close one lane in each direction on Euston Road between 2020 and 2026 to accommodate work on High Speed 2.

The AA said the works were the largest ever proposed in London and would affect far more than local traffic due to its Inner Ring Road status.

[3] Designed by William and Henry Inwood and costing around £90,000 (now £10,359,000), it was the most expensive religious building in London since St Paul's Cathedral, completed in the previous century.

Its library holds about half a million books, including more than 6,000 Sanskrit manuscripts and the largest collection of Hindi and Punjabi medical documents in Europe.

It was built between 1925–7 and holds the society's library dating back to 1673, including George Fox's journal covering the foundation of Pennsylvania.

314 in 1934 by William Coldstream, Victor Pasmore and Claude Rogers to encourage artwork in an atmosphere different from traditional art schools.

96 Euston Road in 1999 into a new complex designed by Colin St John Wilson and opened by Queen Elizabeth II.

[36] In Oscar Wilde's The Picture of Dorian Gray, the characters Sibyl and James Vane live at a "shabby lodgings" on Euston Road.

[37] The street is a property in the United Kingdom edition of the board game Monopoly, which features famous London areas on its gameboard.