Lysacek was the 2010 United States Olympic Committee's SportsMan of the Year,[1] and the winner of the James E. Sullivan Award as the top U.S. amateur athlete of 2010.

[8] Lysacek studied acting at the Professional Arts School in Beverly Hills,[8] and appeared in the independent short film Skate Great!, playing a Russian Olympic gold medalist.

[9] Lysacek is of half-Czech descent; his paternal great-grandfather František Lysáček emigrated from Czechoslovakia's Moravia region to Chicago in 1925.

[13] In 2014 Lysacek joined the Charter Realty and Development team as a Property Representative, Commercial Leasing as his first step in transition from Olympic sport into the Corporate World.

In 2015, Lysacek was hired by the Vera Wang Group to work as a strategic consultant in retail store development.

In this role, Lysacek led marketing, advertising, and creative services efforts for Vera Wang Group, with emphasis on creating value for both internally operated product lines, as well as licensed partnerships.

Lysacek resigned from his position in 2019, in order to join his wife, Duangpatra Bodiratnangkura in her residential real estate development company.

In 1997, he moved up to intermediate and won the pewter medal (fourth place) at the Junior Olympics, after winning both his regional and his sectional qualifying competitions.

[26] He was the first male skater since Terry Kubicka to win back-to-back novice and junior men's titles in the United States.

[21][27] The win on the junior level was unusual in that Lysacek moved from third to first overall while sitting backstage, because he won through a tiebreak in the 6.0 ordinal system.

[28] Following the U.S. Championships, he was assigned to the 2000 Gardena Spring Trophy in Urtijëi, Italy, where he won the silver medal at the junior level.

Lysacek performed two clean programs and came in second behind fellow American Johnny Weir, giving the United States both a gold and a silver on the World Junior podium for the first time since 1987.

[32][33] Over the next season, Lysacek dealt with several injuries, including broken ribs, which resulted in lost training time.

[21] After graduating from high school in 2003, Lysacek made a coaching change and began to work with Ken Congemi and Frank Carroll in El Segundo, California.

Lysacek was the only American man to qualify for the 2005–2006 Grand Prix Final,[45] but withdrew before the event because of bursitis and tendinitis in his right hip.

He was fourth after the short program, but made yet another comeback in the free skate, landing a clean quadruple combination to earn a new personal best and to win his second Four Continents title.

[61] At the 2007–2008 Grand Prix Final, Lysacek was credited with a quadruple jump in both programs,[62][63] and won the bronze medal overall, after placing third in both segments of the competition.

A week before the event, he was forced to withdraw due to an injury sustained while attempting a triple Axel; the blade broke off of his boot and he injured the left side of his body, from his forearm to his shoulder, and required a cast.

[81] At the World Championships, Lysacek competed with a stress fracture in his left foot, which prevented him from trying a quadruple jump at the competition.

[85] Lysacek began the 2009–2010 season at the 2009 Cup of China,[86] where he placed third in the short program and second in the free skating to win the silver medal overall.

[89] At the Grand Prix Final, Lysacek placed second in the short program and won the free skating to win the title overall.

He resumed training with Frank Carroll at Lake Arrowhead, California, and his publicist said he would make a decision whether to compete later in the summer.

[111] On November 20, 2012, Lysacek underwent surgery to repair a torn muscle in his lower abdomen, with an expected period of six weeks off the ice.

[114] On December 10, 2013, Lysacek announced on The Today Show that he would not attempt to qualify for the 2014 Winter Olympics due to the labrum injury that he sustained in September.

[21][42] Lysacek moved to El Segundo, California, to work with Frank Carroll and Ken Congemi in June 2003.

He participated in Target – A Time for Heroes, a celebrity charity event benefiting the Elizabeth Glaser Pediatric AIDS Foundation.

[127] Following his win at the 2009 World Figure Skating Championships, Lysacek acquired many sponsors, including Coca-Cola, AT&T, and Ralph Lauren.

[103] Lysacek left Creative Artists Agency in April 2012 and was represented by Shep Goldberg until his death in November 2014.

[17][128] In April 2012, the U.S. Department of State's Bureau of Educational and Cultural Affairs named Lysacek a Sports Envoy.

[129] In the past, Lysacek has worn costumes designed by Christian Dior,[130] Gianfranco Ferre,[131] Alexander McQueen,[131] and Vera Wang.