Large towns in Indiana include Chandler, Fort Branch, McCutchanville, and Newburgh.

Cities in Kentucky include Henderson, Dixon, Providence, and Robards and currently covers an area of 2,367 sq mi (6,130 km2).

It was originally designated the Evansville, Indiana, standard metropolitan area and was formed by the United States Census Bureau in 1950, consisting solely of Vanderburgh County, Indiana.

Because it includes counties in both Indiana and Kentucky, the Evansville metropolitan area is sometimes referred to as "Kentuckiana".

The entire region is usually referred to as the Tri-State because of Illinois bordering Posey County less than 20 miles west of Evansville and to distinguish it from the Louisville metropolitan area.