A daughter of activist Ali Hewson and singer Bono, she had her first major role in the 2011 drama film This Must Be the Place, and subsequently starred in the 2014 series The Knick.

[5] In 2009, she commenced studies in acting, with subsidiary focus on psychology, at New York University's Tisch School of the Arts, graduating in 2013.

[15] In August 2019, it was announced Hewson had been cast in the role of Adele on the Netflix psychological thriller miniseries Behind Her Eyes, which premiered in 2021.

Broadcast on BBC One in June, it was based on Eleanor Catton's 2013 novel, set in New Zealand during the gold rush of 1866, and also starred French actress Eva Green.

She plays Anna Wetherell, a young woman who migrates to the country's South Island and is soon trafficked into the sex trade.

[18] In 2024, she joined the Netflix mini-series The Perfect Couple alongside Nicole Kidman, Liev Schreiber, and Dakota Fanning.