[1] She graduated from University of the Philippines (UP) in 1964 with a degree in home economics, major in food and nutrition.

Following her husband's death in August 2012, she ran for his vacant seat in the 2013 elections and won, garnering 55,425 or 50% of the total votes cast.

In the 17th Congress, Guevara-Escudero served as the chairperson of the Committee on Basic Education and Culture from 2016 to 2017.

[7] She also served as vice-chairperson of the Committee on Ethics and Privileges,[8] and was a Deputy Speaker from August 2018 to June 2019 during the speakership of Gloria Macapagal Arroyo.

In 2019, she filed a bill that would seek to remove homework as a requirement for Kinder to Grade 12 students.