The film was produced by Elysa Dutton and Leslie Morgenstein and stars Amandla Stenberg and Nick Robinson and follows a young woman named Maddy Whittier (Stenberg) who has a serious medical condition that prevents her from leaving her home, and her neighbor, Olly Bright (Robinson), who wants to help her experience life and they begin falling in love.

Principal photography began on September 6, 2016, in Vancouver, British Columbia, and wrapped up the next month on October 7, 2016.

In suburban Los Angeles, 18-year-old Maddy Whittier is being treated for the immune disorder SCID by her mother, Pauline.

Deducing that Maddy and Olly have been seeing each other behind her back, she forbids their relationship and later fires Carla for betraying her trust.

Deciding it's time she took matters into her own hands, and using a credit card she had previously opened online, she buys tickets to Hawaii, and convinces Olly to go there with her.

On the way to the airport, Olly calls his sister, Kara, telling her that he’s going to Hawaii with Maddy for a couple of days and to take care of their mother.

A doctor from the hospital in Hawaii calls Maddy to give her an update, telling her that she doesn't have something as severe as SCID.

A doctor confirms Maddy has never had SCID, just an underdeveloped immune system from under-exposure due to spending most of her life in filtered air.

[4] In North America, the film was released alongside Alien: Covenant and Diary of a Wimpy Kid: The Long Haul, and was projected to gross $10–12 million from 2,801 theaters during its opening weekend.

The website's critical consensus reads, "Everything, Everything should tug young adult heartstrings fairly effectively, but may not be quite engrossing enough to woo less melodramatically inclined viewers.