Brandi Cunningham from VH1's Rock of Love with Bret Michaels and horror icon Bill Moseley also make appearances in the film, which spawned a franchise of sequels.
Nerdy college student Alistair McDowell moves in with law school drop-out Larnell, and his current roommates typical "surfer-stoner" Bachman and former baseball player Brett.
He is introduced to one of the strippers (Kristen Cladwell) who has skulls on her bra that start biting his neck, killing him, while Ooga Booga watches on, masturbating.
Once he finds a stoned Janet, Eebee reveals her motives: to control the world by turning the air into pot smoke and the oceans into bong water, making everyone massive stoners.
Rare for a direct to DVD film, an associated soundtrack is available on Lakeshore Records and features music from Twiztid, Insane Clown Posse, Sen Dog (from Cypress Hill), and Volume 10 ("Pistol Grip Pump").
The review also argues that the vernacular used by the stoners of the film would be considered "total narc lingo" by "any true High Times subscriber".
When half his friends die after smoking from Eebee, Jimbo locked her in his attic where she stayed until his wife sold it, leading to the events of the first film.
Larnell and Rabbit go inside the hut where Velicity explains that her father uncovered a prehistoric strain of marijuana cultivated by an ancient people, "the Poontang Tribe".
Larnell and Alister enter find the tribe rolling Rabbit up in giant paper, turning him into a massive joint that King Bong shrinks down to a normal size with his necklace.
He immediately pushes conspiracy theories on Al, claiming James Cameron is an alien and that all forms of government agencies are corrupt.
He also explains he is running from the government, living off-grid and training in fighting with a "Ninja Master" Wong Dong, who is really just a car stereo thief.
Larnell suggests they contact his grandfather, Cyril (now a medical marijuana doctor going by Dr. Weed) who shows up with his assistant Nurse Hookah.
Space Bong insults Eebee, so she and Cyril agree to help the gang stop the alien invader, who thinks he can outsmart everyone.
In a final scene, Cyril and Nurse Hookah find the original meteor, the crash site now having been overgrown with the alien weed.
Larnell now owns and operates "Dick's Head Shop" with girlfriend Velicity, and they briefly recount the events of the first three Evil Bong films in passing.
Larnell's assistant String, a gruff little person with a fake eye patch, deals with Hambo, who is looking to sell an Ooga Booga replica to the store for some fast cash.
String refuses Ham I'd offer when two tourists, entirely depicted through racist Asian stereotypes, enter the store asking for directions.
Rabbit enters the shop, now a traveling salesman after renouncing the Priesthood due to the church's stance on marijuana and bearing Evil Bong merchandise.
It also covers her history, which is when Larnell walks in and asks Sarah to visit his store so they can form a partnership promoting their two small business and she leaves.
It is revealed that after defeating Space Bong, Brett and Bachman admitted their love for each other, moved to San Francisco and were married, to everyone's surprise.
Eebee convinces the Gingerdead Man she has the power to restore his human form if he smokes from her and enters the Bong World too so he follows Sarah and Larnell.
King Bong uses his Poontang Tribeswomen to send Gingey to the Pastry Tribunal, a court consisting of Cream Puff, Baguette, Tiny Tart, and Rasta Brownie where he is sentenced to eternal damnation: to be eaten and reformed repeatedly and forever.
Larnell's Dad returns and continues insulting him, and a group of rednecks and duo of stoners begin causing trouble at the shop.
Eventually, Lucy's true intentions are revealed, and the latter drags Faux Batty Boop and Velicity to Sexy Hell and turns on Eebee.
The Gang rent a hotel, which is run by the ghosts of the stoner duo, Gingerweed Man and Faux Batty Boop start a relationship while Eebee tries getting Velicity into smoking.
After him and his girlfriend Barbara reminisce about his father Rabbit, Gingy delivers to a man named High, who is known to sell bizarre junk to the former.
Once he finishes his smoke break, Gingy takes Buddy back to his apartment, but Barbara gets increasingly annoyed of his antics, but eventually starts to like him.
Gingy gets the help of Ooga Booga to hack into the F. U. HQ website to uncover information about where it is located, The two head off to rescue Buddy and Barbara.
In Beverly Hills, California, confirming the location where the franchise takes place, Rabbit opens up a restaurant hoping to give up on marijuana altogether.
A woman named Tom Atkins gets hired by Rabbit to run for the restaurant, He explains he got the money to open it up due to Larnell being sucked into his mind and leaving behind cash.