[4] Pesquet was transported to the ISS on SpaceX Crew-2 in April 2021, joined by NASA astronauts Shane Kimbrough and Megan McArthur and Japan Aerospace Exploration Agency (JAXA) astronaut Akihiko Hoshide.

[5] Crew-2 from Expedition 65 extended their tour of duty on the ISS to become part of Expedition 66,[6] along with Russian cosmonaut Pyotr Dubrov and NASA astronaut Mark Vande Hei, who both launched on Soyuz MS-18 and returned to Earth on Soyuz MS-19, following their extended mission.

Russian cosmonaut Shkaplerov launched on Soyuz MS-19, along with two participants in the joint film project between Roscosmos and Channel One, The Challenge: film director Klim Shipenko and actress Yulia Peresild.

SpaceX Crew-3, launched 10 November 2021, carried NASA astronauts Raja Chari, Thomas Marshburn, and Kayla Barron and ESA astronaut Matthias Maurer to the ISS.

[8] However, continued international collaboration has been thrown into doubt by the 2022 Russian invasion of Ukraine and related sanctions on Russia.