The expedition began upon the departure of Soyuz MS-19 on 30 March 2022[1] with NASA astronaut Thomas Marshburn taking over as ISS commander.

[2][3] Initially, the expedition consisted of Marshburn and his three SpaceX Crew-3 crewmates Raja Chari, Kayla Barron, and Matthias Maurer, as well as Roscosmos cosmonauts Oleg Artemyev, Denis Matveev, and Sergey Korsakov, who launched aboard Soyuz MS-21 on March 18, 2022 and transferred from Expedition 66 alongside the Crew-3 astronauts.

[4] However, continued international collaboration has been thrown into doubt by the 2022 Russian invasion of Ukraine and related sanctions on Russia.

[5] During Expedition 67, the space station was also visited by the crew of Axiom Mission 1, a space tourist mission that brought three spaceflight participants to the station on April 9, 2022 along with former NASA astronaut Michael López-Alegría, who had previously commanded the station during Expedition 14.

Crew-3 departed on May 5, 2022[6] and was replaced by SpaceX Crew-4, which ferried NASA astronauts Kjell N. Lindgren, Bob Hines and Jessica Watkins, as well as ESA astronaut Samantha Cristoforetti, to the station.