Initially, the expedition consisted of Cristoforetti and her three SpaceX Crew-4 crewmates Kjell N. Lindgren, Bob Hines, and Jessica Watkins, as well as Roscosmos cosmonauts Sergey Prokopyev, Dmitry Petelin, and American astronaut Francisco Rubio, who launched aboard Soyuz MS-22 on September 21, 2022 and were transferred from Expedition 67 alongside the Crew-4 astronauts.

[6] After observation and imaging of the damaged spacecraft, in January 2023, Roscosmos and NASA announced that due to the leak, the MS-22 vehicle could not safely return the crew, except in an emergency.

Due to this, Russian officials on the ground had postponed the uncrewed launch of the Soyuz MS-23 until an investigation was conducted or a cause was found.

Roscosmos conducted a thermal test of MS-22, which lost coolant agent in the external contour due to the damage of the radiator.

Previous mission: Expedition 67 29 September 2022 – Soyuz MS-21 Undocking; Official switch from Expedition 67 6 October 2022 – SpaceX Crew-5 Docking 12 October 2022 – ISS Expedition 68 Change of Command Ceremony from Samantha Cristoforetti to Sergey Prokopyev 14 October 2022 – SpaceX Crew-4 Undocking 9 November 2022 – CRS NG-18 Capture & Berthing 23 October 2022 – Progress MS-19/80P Undocking 27 October 2022 – Progress MS-21/82P Docking 15 November 2022 – EVA 1 (US-81): 7 hrs, 11 mins 17 November 2022 – EVA 2 (VKD-55): 6 hrs, 25 mins; installed a work platform called the SKKO (translation: Nauka means of attachment of large payloads) on the Nauka module 27 November 2022 – CRS SpX-26 Docking 3 December 2022 – EVA 3 (US-82): 7 hrs, 5 mins; installed an iROSA at Array 3A 14 December 2022 – Soyuz MS-22 Leak, cancelled Russian EVA[12] 22 December 2022 – EVA 4 (US-83): 7 hrs, 8 mins; installed the fourth iROSA at Array 4A 9 January 2023 - CRS SpX-26 Undocking 17/18 January 2023 - Rubio's seat liner moved from Soyuz MS-22 to Crew-5 20 January 2023 - EVA 5 (US-84): 7 hrs, 21 mins 2 February 2023 - EVA 6 (US-85): 6 hrs, 41 mins 11 February 2023 - Progress MS-22/83P Docking 11 February 2023 - Progress MS-21 Leak Event 18 February 2023 - Progress MS-21/82P Undocking 26 February 2023 - Soyuz MS-23 Uncrewed docking 2 March 2023 - Prokopyev and Petelin's seat liner moved from Soyuz MS-22 to Soyuz MS-23 3 March 2023 - SpaceX Crew-6 Docking 6 March 2023 - Rubio's seat liner moved from Crew-5 to Soyuz MS-23 11 March 2023 - SpaceX Crew-5 Undocking 15 March 2023 - Thermal test of Soyuz MS-22 by onboard cosmonauts to check how much it will heat up and whether it can be used for emergency evacuation from the ISS in case of any incident 16 March 2023 - CRS SpX-27 Docking 28 March 2023 - Soyuz MS-22 Uncrewed undocking; official switch to Expedition 69 Next: Expedition 69 Samantha Cristoforetti's mission for ESA on Expeditions 67 and 68 was named Minerva.