The event will return to its traditional 5-year scheduling cycle after the 2020 edition was delayed to 2021 due to the COVID-19 pandemic.

All other countries wishing to organise World Expo 2025 had until 22 May 2017 to submit their own bids, after which the project examination phase started.

A secret ballot took place to select the winner at BIE's 164th General Assembly on 23 November 2018.

[12] The theme "Saving Lives" includes infant vaccinations, sanitation, lifestyle (diet and exercise) and extending lifespans.

[14] The Expo will be held on an artificial island called Yumeshima, located in Osaka Bay, with a view of the Seto Inland Sea.