The South Florida Bulls men's basketball team used Expo Hall as their main home arena for the 1979–80 season before the on-campus USF Sun Dome opened.

The Tampa Bay Rowdies of the defunct North American Soccer League used Expo Hall for 8 of their 16 home games during the 1983–84 indoor season.

The facility's seating capacity of 10,425 proved too small for the Lightning, and the team relocated to the ThunderDome in St. Petersburg for three seasons, until its permanent home, Amalie Arena, was built in downtown Tampa.

In 1994 the expansion Tampa Bay Tritons of Roller Hockey International played for one season at Expo Hall before folding.

Noteworthy entertainers to perform in concert at Expo Hall include Robert Plant, REO Speedwagon, Cheap Trick, No Doubt, Green Day, Nine Inch Nails, Peter Frampton, Stone Temple Pilots, Yes, George Michael, Santana, Beastie Boys, Alabama, Motörhead, and the Smashing Pumpkins.