[12] The Rodriguez sisters, lead guitarist Alexia and bassist Anissa,[13] along with vocalist Lindsey Vogt started the band in 2003.

[12] The World Outside received widespread critical acclaim and the group was featured on the cover of USA Today, as one of Alternative Press Magazine's "100 Bands You Need To Know", and hosted an episode of MTV's Headbangers Ball.

In early 2006 Alex Torres (rhythm guitar), Corey Pattakos (backing vocals), and Caleb Clifton (drums) joined and recorded a nine-song EP, When Silence Is Broken, the Night Is Torn, at Larry Elyea's Glendale, Arizona home studio: Mind's Eye Digital Recording Studios.

They released White Lotus through a joint venture between their own label Foresee Records and Maphia Entertainment on August 9, 2011.

[5] On December 20, 2012, they reached 1,000,000 likes on Facebook prompting them to release a free download of a new demo for their upcoming album.

[26] On July 10, they announced that they were forced to cancel an Oklahoma City show due a health issue with Anissa Rodriguez.

To promote the tour, Eyes Set to Kill and One-Eyed Doll recorded a cover of Depeche Mode's "Enjoy the Silence".

[30] In 2017, Alexia Rodriguez formed band The Secret Destroyers with former vocalist Lindsey Vogt and Teresa Brenneman.

[31][32] On February 18, 2021, Eyes Set To Kill premiered new single "Find Our Way" via SiriusXM Octane, their first with new label Revival Recordings.