[2] His appointment to the Secretariat of Foreign Affairs by President Manuel Ávila Camacho marked an end to the Post-Revolutionary domination of politicians from the North of the country.

With his co-cabinet member Miguel Alemán Valdés (Secretary of the Interior), he "gave Mexico the most progressive foreign policy and the most orderly internal government in the nation's history".

During World War II, he was a strong proponent of inter-American unity and led conferences of the foreign ministers of countries of the Americas to this end.

Also, the fact that he was not exiled after the campaign is considered something of a victory for Mexican democracy, which had been intolerant of opposition parties and candidates since solidification of the PRI.

[5][6] As a result, for the first time in human history, a World Constituent Assembly convened to draft and adopt the Constitution for the Federation of Earth.