The Ezra Yaghoub Synagogue (Persian: کنیسه عزرا یعقوب) is an Orthodox Jewish congregation and synagogue, located in the Old Jewish Quarter, in the Oudlajan neighborhood of Tehran, Iran.

The synagogue was established during the reign of Naser al-Din Shah Qajar and was repaired and restored many times since then.

Ezra Yaghoub, for whom the synagogue is named, was a prominent Iranian Jewish merchant and was the first person to make business contact with the city of Manchester in England.

After his death, aged forty years, his widow spent most of his fortune on charity for the Iranian Jews.

This article about a synagogue or other Jewish place of worship in Iran is a stub.