Born in Nobres, Mato Grosso, Fábio represented União Bandeirante-PR, Atlético-PR and Vasco, where he won the Campeonato Brasileiro and the Copa Mercosur in 2000.

In November 2007, after speculation mounted on a possible move in the January 2008 transfer period, it was announced Fabio would extend his Cruzeiro contract until December 2009.

[15] During both the 2013 and 2014 Campeonato Brasileiro Série A winning campaigns, Fábio served as Cruzeiro's captain and thus lifting the Brasileirão trophy twice in a row for the team.

Fábio was selected in 2013 as the best goalkeeper in Brazil, winning the prestigious Bola de Prata trophy for the position for the second time, having also been honored in 2010.

Being called up by Brazilian head coach Dunga for a friendly against Norway in Oslo on 16 August 2006, though never had playing time, the game ended 1–1.

Brazil has great keepers as the level has really gone up over the past few years and we have goalies of the calibre of Rogério Ceni (São Paulo), Fábio Costa (Santos) and Júlio César (Internazionale).