He played in Major League Baseball (MLB) for the Chicago Cubs, Baltimore Orioles, and Pittsburgh Pirates.

Pie was a highly touted young prospect, and put on the fast-track to reach the big-league club, although he did not start the 2007 season in the major leagues.

Pie was called up from Triple-A Iowa on April 17, 2007, and was in the starting lineup, replacing the injured Alfonso Soriano.

Pie got his first major league hit on April 17, 2007, a double off Greg Maddux of the San Diego Padres.

Pie recorded his first major league home run on April 27, 2007, off Anthony Reyes of the St. Louis Cardinals.

[3] However, the Cubs recalled Pie from the minors in order to replace an injured Alfonso Soriano and Ángel Pagán on August 8, 2007.

When the Cubs traded their starting left-handed center fielder Jacque Jones in November 2007, general manager Jim Hendry indicated that the club wasn't necessarily looking outside for a veteran, with Pie and Sam Fuld in the mix.

[4][5][6] "He's ready to go out there in spring training lined up next to Pie and compete to play center field", Hendry said of Fuld.

[11] On January 18, 2009, Pie was traded to the Baltimore Orioles for Garrett Olson and Single-A pitcher Henry Williamson.

While on the bench for most of June and July, Pie worked extensively on improving his swing and pitch recognition with Orioles' hitting coach Terry Crowley.

[13] Injuries to Orioles' center fielder Adam Jones and Nolan Reimold's nagging Achilles problem allowed Pie to play more regularly later in the season, and he showed significant improvement compared to his April performance.

[14] Pie won the starting left field assignment in 2010 after a very strong spring, but landed on the 60-day disabled list not long into the season, where he remained until July 6, 2010.

[11] On May 12, 2012, Pie signed a minor league contract[17] with the Atlanta Braves and played for the AAA affiliate Gwinnett.

[11] On November 19, 2012, Pie signed a minor league deal with the Pittsburgh Pirates with an invitation to Spring training.