The Federal Correctional Institution, Williamsburg (FCI Williamsburg) is a medium-security United States federal prison for male inmates in Salters, South Carolina.

It is run by the Federal Bureau of Prisons, a division of the United States Department of Justice.

FCI Williamsburg is located in the town of Salters 90 miles southeast of Columbia, the state capital.

[1] On October 27, 2010, US Attorney General Eric Holder presented an Outstanding Contribution Award to Henry R. Mills, an Air Conditioning Equipment Mechanical Supervisor at FCI Williamsburg.

Mills developed more efficient means of cooling 18 ice machines in use at the facility, lessening their environmental impact via a reduction of more than 2.5 million gallons of water annually.