The units featured a 1,000-horsepower (750 kW), six-cylinder opposed piston prime mover, and were configured in a B-B wheel arrangement mounted atop a pair of two-axle AAR Type A trucks, with all axles powered.

These styling cues were carried through to the H-10-44's successor, the FM H-12-44, until September 1952 when the exterior design was "Spartanized" to reduce production costs.

Most notable of these is Milwaukee Road #760 (originally delivered as #1802), the first Fairbanks–Morse locomotive constructed in their own plant, which is preserved and operational at the Illinois Railway Museum.

Another example is former Hallet Dock Company HD-11, which is now at the Lake Superior Railroad Museum in Duluth, Minnesota.

A reproduction H-10-44 locomotive sits atop the Wood Family Fishing Bridge, a former railroad bridge which crosses the Rock River several hundred yards south of the foundry where the H-10-44s were built, in Beloit, Wisconsin.