The F Line's northern terminus was at 18th Street in downtown Denver.

It shared track with the D Line from 18th Street to I-25 & Broadway, then operated along the Southeast Corridor to Lone Tree, sharing tracks with the E Line.

[1] On September 20, 2020, Regional Transportation District suspended the F Line due to the ongoing coronavirus pandemic.

[3] The 2004 voter-approved FasTracks initiative included the Southeast Corridor extension for the E and F Line, which extended the lines by 2.3 mi (3.70 km) to southern Lone Tree.

[4] It included three new stations, Sky Ridge, Lone Tree City Center, and RidgeGate Parkway, the latter with a 2,000-stall parking facility.