His career started in 1990 at the age of 17 when he began to sing with a small rock and roll underground group who played classics of 1950s and 1960s similar to Elvis Presley's songs.

[citation needed] He had a passion for groups such as Queensrÿche, Fates Warning, and Crimson Glory, which inspired him to form his own heavy metal band.

Shortly after, in 1993 the band started to work on a demotape called Midnight Resistance, lyrics and vocal lines written by Lione.

Lione and the other members of Athena attended Axel Rudi Pell Tour 1998 with Dreamscape, another progressive metal band from Germany in December.

In 1998, Lione met Olaf Thorsen and to seal their newfound friendship, they decided to create what was originally supposed to be only a side-project: Vision Divine.

The first "Vision Divine" record in 1999 received excellent sales results and criticism (and took the band on tour in South America for the first time).

In 2003, Lione sang at shows with Vision Divine at Gods of Metal 2003 (Milan) and at Heineken Jammin' Festival (Imola) in June.

He nevertheless spent most of the year writing and left the band nine new vocal lines for the "Stream of Consciousness" album, executed with a different singer.

Rhapsody first began negotiations with Lione at Gate Pathway Studio in Wolfsburg, Germany after hearing him in the "Piece of Time" album from Labyrinth.

Lione performed on stages with Rhapsody at Gods of Metal 2001 (Milan) in June, during South American Tour (Mexico, Colombia, Brazil and Chile) and at Rock Machina Festival (Spain) in July.

Rhapsody travelled with Stratovarius and Sonata Arctica on a successful European tour in April and May 2000 when they also had a chance to join the Wacken Festival 2000 in Germany.

In February 2004, he finished vocals for Rhapsody's new album Symphony of Enchanted Lands II: The Dark Secret.

The band went promo tour for their new album throughout Canada, US, Germany, Sweden, Czech Republic, Greece, and the UK.

Triumph or Agony was released in 2006, followed by The Frozen Tears of Angels and The Cold Embrace of Fear – A Dark Romantic Symphony in 2010 and From Chaos to Eternity in 2011.

The two shows were a great success and Fabio was again with them at the Live n' Louder Festival in São Paulo with Twisted Sister, Metal Church and Loudness.

After that, the band decides to do a special tour, a commemorative one celebrating 20 years from the release of the first record "Angels Cry".

After that Angra played in Japan as co/headliner at the Loud Park festival 13 with Stone Temple Pilots and Europe and they had a very good response.

Angra announced that the band's new release, and the first album to feature vocalist Fabio Lione, entitled Secret Garden.