Fabio Mussi (born 22 January 1948) is an Italian politician, formerly Minister of University and Research in the Prodi II Cabinet.

Born in Piombino, Tuscany, he joined the Italian Communist Party (PCI) in 1966, being initially active at university level whilst studying at the Scuola Normale Superiore in Pisa.

He also became a member of the PCI Central Committee in 1979, charged with cultural and propaganda tasks and bestowed with an editor's position at Rinascita.

He was regional secretary of the party in Calabria (1980–1984), and after that a member of the PCI National Directory.

Confirmed as deputy for his fourth time at the 2006 elections, Mussi then served as senior vice-president of the Chamber of Deputies and Minister for the University and Research in the Italian government.