Born in Rome to parents from Bologna, Frizzi began his career in 1980, successfully auditioning to host the children's show Il barattolo for Rai 2 in 1980.

Starting from the early nineties, Frizzi presented several prime-time RAI TV shows, including I fatti vostri, Scommettiamo che...?

[1][2] He also became presenter of the annual celebrity football match Partita del cuore, which raised funds for charity and scientific research, and hosted various editions of the Italian Telethon.

As his popularity increased he also returned to Telethon and Partita del cuore, charity TV and sports events which he had championed in the 1990s.

Frizzi also made a guest appearance in the Italian dubbed version of The Simpsons on the episode Pay Pal in which he voiced John Wilkes Booth.

On 23 October 2017, while recording an episode of L'eredità, Frizzi suffered an ischemic stroke, which led him to take a break from work.

[6] His funeral, attended by thousands, was held two days later at the Basilica di Santa Maria in Montesanto located in the Piazza del Popolo in Rome, commonly known as the Chiesa degli artisti, the "Church of the Artists".