Fadrique de Toledo Osorio, 1st Marquess of Valdueza (30 May 1580 – 11 December 1634), was a Spanish Navy officer and nobleman.

He served in the Spanish fleet under command of his father and rose quickly through the ranks, as did his elder brother García de Toledo Osorio, 6th Marquess of Villafranca.

In 1617, he became Captain General of the Ocean Sea Navy, replacing the late Admiral Luis Fajardo.

This victory would prove decisively important in the Dutch-Portuguese War to oust the Dutch from Brazil over the next two decades.

In 1629 he commanded a Spanish expedition that expelled the English and French colonial settlers from the islands of Saint Kitts and Nevis.