[6][7] Mustafa started his acting career with Umrao Jaan Ada and had success with the dramas Main Abdul Qadir Hoon, Ek Tamanna Lahasil Si, Daagh, Kankar and Dusri Biwi.

[11] Although he initially pursued a degree in doctor of pharmacy at the Baqai Medical University in Karachi, but he dropped out before completing his studies.

His other notable television serials include Yeh Zindagi Hai, Haal-e-Dil, Bahu Rani, Ae Dasht-e-Junoon, Masuri, Aashti, Pul Siraat, Mastana Mahi, Main Abdul Qadir Hoon, and Koi Nahi Apna.

In 2017, he hosted the launching ceremony for the Karachi Kings, a Pakistan Super League team franchise.

[21][22] In 2018, he starred in Nadeem Baig's Jawani Phir Nahi Ani 2 and Qureshi's Load Wedding; both of which released on same day, 22 August 2018.