[7] In the mid-1970s, following the development of the Trans-Alaska Pipeline, Alaska Airlines and Braniff International offered "interchange service" between Fairbanks and Houston via Anchorage, Seattle and Dallas.

The station was originally opened after the acquisition of Pacific International Airways and used for short-haul services to Juneau, Seattle, Ketchikan, Whitehorse and other destinations.

[10] Pan Am intended to use Fairbanks as a stop for service to Asia as early as 1931, but initial difficulty in negotiating landing rights with the Soviet Union, followed by the outbreak of World War II, delayed these plans until decades later.

[11] Pan American World Airways eventually used Fairbanks as a stopover for transpacific service from New York and Seattle to Tokyo starting in September 1969.

For the 12-month period ending February 28, 2018, the airport had 119,898 aircraft operations, an average of 328 per day: 58% general aviation, 31% air taxi, 9% scheduled commercial, and 2% military.