Stewie uses his upgradeable laser gun to defeat enemies and conveniently placed "sky hooks" to move through various stages.

Quagmire and Meg work as Repellents for female and male NPC's, respectively, and can force them to do certain things through their repulsiveness.

Chris is the only character of the main cast of the show that is not playable in any way through the entire game (Not even through Stewie's mind control), although he appears as a NPC.

A key feature of the game are mini-games done in the same style as the cutaway gags that the show is famous for, usually lasting less than 10 seconds.

The mini-games often repeat cutaway gags from the episodes, such as Peter inexplicably burning his hand in a waffle iron.

Successfully completing the mini-game offers a bonus: Brian becomes invisible for a short period, while Peter and Stewie receive power-ups for their respective abilities.

Stewie has built a mind control ray, and plans to use it in conjunction with Peter's satellite dish.

Stewie finds Bertram at the top of a missile silo, planning to launch the rocket into orbit so he can project his mind control beam around the world.

Brian's section of the game sees him trying to prove his innocence when Carter Pewterschmidt accuses him of once again impregnating his prize-winning racing greyhound Seabreeze.

Peter, after being smashed on the head by the PTV satellite dish, wakes up in the hospital and sees a spotlight identical to the Bat-Signal, only in the shape of Mr. Belvedere.

Peter takes on the persona of his cousin and blaxploitation film actor Rufus Griffin and destroys the entire arcade before waking up in the closet.

As he arrives, the debris of Bertram's rocket crashes on him, and Peter emerges as ANNA, an android programmed to destroy Mr. Belvedere.

In the final battle of the game, Peter defeats the Chicken, and just barely escapes a massive explosion in a penthouse, landing safely on top of Meg who, along with Lois and Chris, had inexplicably been standing in the middle of the street.

After getting up from Meg and rejoining his family, Peter sees the Belvedere spotlight again which turns out to be Mayor Adam West (which almost starts referencing the Batman TV series) making shadow puppets.

However, with concepts like jumping on pregnant women's stomachs to shoot babies out and prisoners in the shower scrubbing each other down, this game is in no way kid friendly.

Club gave the game a D and stated that it was "littered with gags that flop, and knock-offs from the TV show that look terrible [...] The writing is crass enough to earn a "Mature" rating, yet Family Guy plays like it's meant for 6-year-olds.