She soon appeared in Venice, Florence, Milan, Naples, and other Italian cities, in Tancredi, La gazza ladra, Il pirata, L'elisir d'amore and other operas.
"[4] He chose her to create title roles in three of his operas, Rosmonda d'Inghilterra with Gilbert Duprez as Enrico II (at Florence in February 1834),[5] Pia de' Tolomei (Venice, 1837, a work conceived expressly for her from the beginning[6]), but most notably that of Lucia in Lucia di Lammermoor in Naples in 1835, one of the immortal roles of Romantic opera.
[9] In 1841 she made a tour with Rubini through various European cities including Brussels, Wiesbaden, The Hague, Bayonne, Madrid and Bayeux.
[13] The heyday of Mme Persiani's career spanned from the 1830s to the 1850s, and was primarily in Paris and London, but with significant appearances in Vienna and St Petersburg.
Mme Tacchinardi Persiani retired from the stage in 1859, and thereafter she and her husband gave vocal training in Paris, where she died.
She was one of the first sopranos of the "nightingale" category, a harbinger of others such as Jenny Lind, Adelina Patti, Nellie Melba, Amelita Galli-Curci, etc.