[5][6][7] After getting exposed to cosmic radiation, Reed Richards, Susan Storm and Ben Grimm, alongside their robot H.E.R.B.I.E., fight crime as the Fantastic Four.

[8][9] Universal Pictures executive Frank Price had optioned several Marvel Comics including the Human Torch and as a result the series wasn't allowed to feature the character.

[9] With the rights to one of the central characters tied up, Stan Lee decided a new fourth member of the team would be created that would take inspiration from R2-D2 from the successful film Star Wars.

[8] While certain episodes were direct adaptations of the earliest adventures written by Lee and Drawn by Kirby, several alterations had to be done for time limitations and adherence to Broadcast Standards and Practices.

[10] Writer Roy Thomas, who worked on the series alongside Lee and Kirby, spoke about the imitations they encountered such as how The Thing was no longer allowed to hit "anyone, man beast or monster".

[8] In addition to the death of The Thing actor, Ted Cassidy, a second season was ultimately not produced as then NBC President Fred Silverman hated the show.

In July 2012, scenes from Fantastic Four were re-cut, edited, and re-dubbed into comical shorts as part of Disney XD's comedic Marvel Mash-Up series of shorts for their "Marvel Universe on Disney XD" block of programming that included Ultimate Spider-Man and The Avengers: Earth's Mightiest Heroes.