During the first season, Stan Lee was featured speaking before each show about characters in the following episode and what had inspired him to create them.

Most episodes in the first season consisted of fairly accurate re-interpretations of classic 1960s Fantastic Four comic book stories by Stan Lee and Jack Kirby.

[6][7] However, the season's cost-effective animation (provided by Wang Film Productions and Kennedy Cartoons) and attempts to add humor through the inclusion of a fussy British landlady (portrayed by Lee's wife Joan) for the Fantastic Four were generally met with displeasure by fans – to say nothing of then-current Fantastic Four comic book writer Tom DeFalco, who got in trouble for penning a scene in issue #396 of the series that featured Ant-Man watching and lambasting an episode of the cartoon.

In the two-part premiere "The Origin of the Fantastic Four", Puppet Master took control of the Thing and used him to capture Invisible Woman.

In addition, Four Freedoms Plaza replaced the Baxter Building as the Fantastic Four's home base in season 2.

In the second season's premiere episode "And a Blind Man Shall Lead Them" (guest starring Daredevil), Doctor Doom strikes at a now fully powerless Fantastic Four and has his hand crushed by the Thing.

He is sent by Maximus to retrieve the Inhuman Royal Family, after he had usurped the throne and also caused Medusa's amnesia.

Malice's appearance is the result of Psycho-Man using his empathic abilities to make Susan turn against her Fantastic Four teammates.

Just like in the comics, Franklin Storm lost his wife in an accident, and an altercation with a loan shark led to an accidental murder.

When Storm appears, he warns the Fantastic Four to stay away and rolls over on the floor, taking the full force of the deadly concussive blast.

In what turned out to be the series finale, "Doomsday", Doctor Doom acquires the Power Cosmic from the Silver Surfer.

After he is defeated by the villain Ogress, the Gang distributes leaflets marked "THING WHUPPED BY A WOMAN!

Chuck McCann and Beau Weaver reprised their roles (as the Thing and Mister Fantastic respectively) on The Incredible Hulk.

Only Quinton Flynn (who replaced Brian Austin Green as the voice of the Human Torch in the second season) came back for Spider-Man.

Beau Weaver, Lori Alan, and Chuck McCann were replaced by Cam Clarke, Gail Matthius, and Patrick Pinney as Mister Fantastic, the Invisible Woman, and the Thing respectively, and Doctor Doom was voiced by veteran voice actor Tom Kane for parts 2 and 3.

The entire series is available to purchase on the iTunes Store,[30] Amazon Prime Video,[31] and Google TV.

On July 5, 2005, Buena Vista Home Entertainment released the complete series on a 4-disc Region 1 DVD boxset.

[37] In July 2005, Buena Vista Home Entertainment released a Region 2 single-release DVD titled Fantastic Four: A Legend Begins.

[40] Lace International released their remaining stock, including both seasons of the show and a boxset containing all twenty-six episodes in November 2008, with remastered video and audio footage.

Clear Vision later took over UK and German distribution rights, re-releasing the season volumes as separate sets.