Farafangana is a city (commune urbaine) on the south-east coast of Madagascar and capital of the Atsimo-Atsinanana region.

It is at the southern end of the Canal des Pangalanes,[1] with the mouth of the Manampatrana River located on the north side of the town.

[2] Settlements located to the north include Lokandambo, Manambotra, Ambahikarabo and Amboahangimamy, with Ambalolo to the west.

[4] Natives are mainly from ethnic groups Antefasy, Rabakara, Antesaka and Zafisoro.

[6] The Manambato and the Manampatrana River that has its mouth into the Indian Ocean at Farafangana.