Manjoo was a staff writer for Slate magazine from 2008 to September 2013, when they left to join The Wall Street Journal.

As an undergraduate, Manjoo served as writer and editor-in-chief of The Cornell Daily Sun student newspaper.

[1] They were self-described in The New York Times as a "stereotypical, cisgender, middle-aged suburban dad," and said in 2019 that they prefer to be referred to with singular they pronouns.

"[16] In March 2018, they published a column in the Times about a personal experiment in getting most of their news from print sources for two months.

[20][21] In April 2021, their column "Let's Quit Fetishizing the Single-Family Home" was used for the Abitur high school leaving exams in the German state of North Rhine-Westphalia.